Okay. I have a cat picture. I figured out how to get it on Synfig. I can turn it into a PNG from Canva. So I want to make one of the cats eyes wink. It has one eye open and one eye closed. Should I just cut out and duplicate the eye and I don’t know draw it slowly closing? Is that a good way to approach it?
You can use a Switch layer with eye closed/eye open as possibilities.
Don’t forget to use animation mode when doing the change of layer.
You can do a cutout or just displaying the eye in the “non original state” over the picture.
There is not specific approach, it is up to you to decide 
Also Synfig is vector animation first, use of pictures/cutout is for convenience.
But you can use cutout of a character and use a skeleton for example.
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Thanks so much for helping me.